Aquafarian Nano Blue

Tucker D, Lu Y, Zhang Q. — From Mitochondrial Function to Neuroprotection – An Emerging Role for Methylene Blue. Molecular Neurobiology. 2018 Jun;55(6):5137–5153. doi:10.1007/s12035-017-0712-2. https://pmc.ncbi.nlm.nih.gov/articles/PMC5826781/
(This comprehensive review demonstrates that methylene blue acts as a mitochondrial electron carrier, directly protecting mitochondria from dysfunction and oxidative stress. It highlights methylene blue’s neuroprotective, anti-inflammatory, and anti-aging mechanisms, and documents its ability to promote cellular repair, cognitive resilience, and overall energy metabolism.)

Scarparo HC, et al. — Methylene Blue for the Treatment of Health Conditions: a Scoping Review. Brazilian Archives of Biology and Technology. 2021;64:e21210119. https://www.scielo.br/j/babt/a/Wg76pfqfWjQtDrkRZ8bWFNp/?lang=en
(This scoping review synthesizes evidence from recent clinical trials and experimental models showing methylene blue’s safety, broad therapeutic potential, and efficacy for acute and chronic conditions, including neuroprotection, pain relief, cognitive enhancement, and tissue repair. The review confirms methylene blue’s anti-inflammatory, antioxidant, and mitochondrial support effects, with a favorable side effect profile.)

Xue H, Thaivalappil A, Cao K. — The Potentials of Methylene Blue as an Anti-Aging Drug. Cells. 2021 Dec;10(12):3379. doi:10.3390/cells10123379. https://pmc.ncbi.nlm.nih.gov/articles/PMC8699482/
(This review details methylene blue’s ability to enhance mitochondrial function, reduce oxidative stress, and stimulate cell longevity. It summarizes evidence that methylene blue delays brain and skin aging, facilitates wound healing, and may even treat rare progeroid syndromes, highlighting its role in cellular and tissue rejuvenation.)

Poteet E, Winters A, Yan LJ, Shufelt K, Green KN, Simpkins JW, Wen Y, Yang SH. — Neuroprotective Actions of Methylene Blue and Its Derivatives. PLoS One. 2012;7(10):e48279. doi:10.1371/journal.pone.0048279. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048279
(This open-access study demonstrates that methylene blue and its related compounds protect neurons by boosting mitochondrial function, reducing oxidative stress, and enhancing cellular energy metabolism. The authors show that methylene blue can delay senescence, preserve mitochondrial membrane potential, decrease neurotoxicity, and provide robust neuroprotection across models of cognitive and neurodegenerative injury.)

Zhao R, Liang H, Clarke E, et al. — Anti-Aging Potentials of Methylene Blue for Human Skin Longevity. Scientific Reports. 2017 May 29;7:2475. doi:10.1038/s41598-017-02419-3.
https://www.nature.com/articles/s41598-017-02419-3
(This research compared methylene blue’s antioxidant and skin-restoring effects to other common antioxidants in human skin fibroblasts and 3D skin models. Methylene blue significantly improved fibroblast proliferation, delayed cellular aging, and enhanced wound healing, skin hydration, and dermal thickness. The study also found no irritation in in vitro skin models, supporting methylene blue’s safety and efficacy for long-term topical or dermal use.)

Gonzalez-Lima F, Barksdale BR, Rojas JC. — Mitochondrial respiration as a target for neuroprotection and cognitive enhancement. Biochemical Pharmacology. 2014 Sep 1;88(4):584-593. doi:10.1016/j.bcp.2013.11.010. https://www.sciencedirect.com/science/article/abs/pii/S0006295213007417
(This authoritative review demonstrates that methylene blue acts as a catalytic redox agent in neurons, improving mitochondrial respiration and cytochrome oxidase activity. The article documents methylene blue’s proven capacity to enhance cognition, protect against neurodegeneration, and support brain energy metabolism—directly substantiating its value for memory, neuroprotection, and anti-aging supplementation.)

Riha PD, et al. — Memory facilitation by methylene blue: Dose-dependent effect on behavior and brain oxygen consumption. Eur J Pharmacol. 2005 Dec 28;511(2-3):151–158. doi:10.1016/j.ejphar.2005.02.001. https://pubmed.ncbi.nlm.nih.gov/15792783/
(Demonstrates that low-dose methylene blue enhances memory and neural energetics, substantiating claims of cognitive enhancement and neuroprotection.)